Detalhe da pesquisa
1.
Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
Bioorg Med Chem Lett
; 29(12): 1522-1531, 2019 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30981576
2.
Optimisation of a series of potent, selective and orally bioavailable GlyT1 inhibitors.
Bioorg Med Chem Lett
; 19(8): 2235-9, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19318248
3.
Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma.
Sci Transl Med
; 10(468)2018 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30463918
4.
Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.
J Psychopharmacol
; 21(4): 384-91, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17092983
5.
The in vivo properties of pagoclone in rat are most likely mediated by 5'-hydroxy pagoclone.
Neuropharmacology
; 50(6): 677-89, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16430927
6.
Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders.
J Med Chem
; 49(1): 35-8, 2006 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-16392789
7.
Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1.
ACS Med Chem Lett
; 1(7): 350-4, 2010 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900218
8.
Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.
Bioorg Med Chem Lett
; 16(6): 1582-5, 2006 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16384707
9.
Imidazo[1,2-a]pyrimidines as functionally selective GABA(A) ligands.
Bioorg Med Chem Lett
; 16(5): 1175-9, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16406613